What is Cervical Cancer?

The cervix is the lower part of the uterus (womb) that extends into the upper end of the vagina.

Cervical cancer develops in the cervix, the narrow outer end of the uterus that extends into the vagina. When diagnosed early, cervical cancer is curable and patients have an excellent chance of recovery.Most cervical cancers begin in an area called the transformation zone, where the inner part of the cervix closest to the uterus (the endocervix) meets the outer part of the cervix closest to the vagina (the ectocervix).

Every year, approximately 11,000 women are diagnosed with cervical cancer and about half of those women are between the ages of 35 and 55. The majority of cases are caused by exposure to the human papillomavirus (HPV), a common sexually transmitted disease. HPV affects up to 80 percent of females and males in their lifetime. Many cases of HPV clear on their own, but certain types of HPV can cause cervical, vulvar and vaginal cancer in females.

In its early stages, cervical cancer usually has no symptoms. It develops slowly, beginning as a pre-cancerous condition called dysplasia. Symptoms of cervical cancer often do not begin until the cancer spreads into nearby tissue.

As cervical cancer grows, symptoms may include:

  • Continuous vaginal discharge, which may be pale, watery, pink, brown, bloody or foul-smelling
  • Abnormal vaginal bleeding between periods, after intercourse, or after menopause
  • Periods become heavier and last longer than usual
  • Any bleeding after menopause
  • Pain during intercourse

These symptoms can also be caused by other conditions, so it is best to visit  KIMS HOSPITALS  for a diagnosis.

 

Causes  and Risks  of cervical cancer

Anything that increases a woman’s chances of getting HPV or decreases her ability to get Pap smears is a risk factor for cervical cancer.

HPV is spread by sexual contact and is the cause of almost all cases of cervical cancer, as well as many vaginal and vulvar cancers. HPV may cause the cells in the cervix to change. If abnormal cells are not found and treated, they may become cancer.

As many as 80% of men and women who have had sex have HPV. Usually the body’s immune system eliminates the virus, and most people never know they have it. While most women with HPV will not get cervical cancer, they should be aware of the risk and have regular Pap tests.

Smoking and a weakened immune system (caused by a condition such as HIV/AIDS) can also greatly increase the risk of developing cervical cancer.

Cervical cancer risk factors include:

  • Age: The risk of cervical cancer increases with age. It is found most often in women over the age of 40. However, younger women often have precancerous lesions that require treatment to prevent cancer.
  • Smoking: Cigarette smoke contains chemicals that damage the body’s cells. It increases the risk of precancerous changes in the cervix, especially in women with HPV.
  • Sexual behavior: Certain types of sexual activity may increase the risk of getting HPV infection. These include: 1) Multiple sexual partners, 2) high-risk male partners, 3) first intercourse at an early age and 4) not using condoms during sex.

Other cervical cancer risk factors include:

  • Lack of regular Pap tests
  • Having a sexually transmitted disease (STD), including chlamydia
  • Diethylstilbestrol (DES) exposure before birth: This drug was used between 1940 and 1971 to help women not have miscarriages. Women whose mothers took DES during pregnancy have a high risk of vaginal and cervical cancers.
  • HIV infection
  • Weakened immune system: Having an organ transplant or taking steroids raises the risk of developing cervical cancer.
  • Being overweight or not eating a healthy diet

Not everyone with risk factors gets cervical cancer. However, if a woman does have risk factors it’s a good idea to discuss them with a health care provider.

Cervical cancer is classified based on the type of cell where it develops. The most common types of cervical cancer are:

Squamous cell carcinoma (cancer): This is the most common type of cervical cancer and is found in 80% to 90% of cases. It develops in the lining of the cervix.

Adenocarcinoma: This type of cervical cancer develops in gland cells that produce cervical mucus. About 10% to 20% of cervical cancers are adenocarcinomas.

Mixed carcinoma (cancer): Occasionally, cervical cancer has features of squamous cell carcinoma and adenocarcinoma.

In rare instances, other types of cancer, such as neuroendocrine (small and large cell cervical cancer), melanoma, sarcoma and lymphoma, are found in the cervix.

At one time, cervical cancer was considered one of the most serious cancers for women. But thanks to effective screening with the vaginal Pap smear (also called a Pap test), which can detect cervical precancers and cancers early on

More than 90 percent of cervical cancers today are caused by infection with the human papillomavirus (HPV), a virus so common that more than two-thirds of sexually active women are infected with it at some point.

In part because cervical cancer tends to grow so slowly, there are a number of measures that a woman can take to prevent it from spreading and becoming advanced:

  • Have regular Pap smears to screen for any changes in the cells of the cervix.
  • Use condoms regularly to protect yourself from getting HPV.
  • Discuss HPV vaccination with your doctor.

Preventing HPV with Condoms

Other than the presence of genital warts, there is no way of knowing whether a sexual partner is infected with HPV. While condoms do not provide complete protection — HPV can spread through physical contact with infected areas of the mouth, genitalia, and anus — the American Cancer Society reports that using condoms can reduce the rate of HPV infection by about 70 percent. Using condoms regularly also protects against various other sexually transmitted diseases.

HPV Vaccination

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Detecting changes in cells in the cervix as early as possible can prevent cancer or make it easier to treat. Tests including a Pap test and a human papillomavirus (HPV) test are used to look for these changes. (A Pap test is also called a Pap smear, cervical cytology testing, or liquid-based cytology.)

Age Group Recommendation
Women younger than 21 No routine Pap test screening
Women age 21 to 29 Pap tests every three years
Women age 30 to 65 Pap test alone every three years or an HPV test along with a Pap test every five years
Women over 65 No screening necessary if previous screening guidelines have been followed and the woman is not at a high risk for cervical cancer

SPECIAL CONSIDERATIONS FOR MORE FREQUENT SCREENING

Some women should be screened more often. These include women who have a weakened or compromised immune system, who have had precancerous lesions, or whose mothers used the drug diethylstilbestrol while they were pregnant. Talk with your doctor to learn if these circumstances may apply to you.

Many women come us after they have had an abnormal Pap smear that indicates cancerous changes in the cervix during a routine visit to the doctor. When you come to us, our doctors will likely examine the cervix, take a biopsy of cervical tissue, and perform other tests to assess the stage of the cancer.

We may perform one or more of the following tests and procedures:

PAP SMEAR

A Pap smear is a test most commonly used to screen for and detect the possibility of cervical cancer or precancer, called dysplasia.

To perform a Pap smear, the doctor inserts a lubricated instrument called a speculum into the vagina to enlarge the opening, and takes a sample of mucus and cells by gently scraping the cervix. Though the procedure is generally not painful, some women experience a few seconds of minor discomfort.

The tissue samples are then sent to a lab at to be analyzed under a microscope by one of our expert pathologists. Collection, sampling, screening, and interpretation of Pap smears require considerable experience and skill to ensure an accurate diagnosis.

LIQUID-BASED CYTOLOGY

With a Pap smear, cells are applied to a slide and then stained and examined in the laboratory. With liquid-based cytology, the cells are obtained in the same manner as they are for a Pap smear, but instead of being stained they are placed in a liquid, processed in a machine, and then placed on a slide. This test provides higher-quality samples than a Pap smear.

COLPOSCOPY AND BIOPSY

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Early-stage cervical cancer can often be treated with surgery. It’s possible you may not even need other forms of treatment, such as chemotherapy or radiation. The key to treating early-stage cancers or precancers is to catch them early.

Treatment for advanced cervical cancer

Our doctors use an approach called sentinel lymph node mapping to measure your cancer’s potential to metastasize (spread) to other parts of the body. This information can help your treatment team determine the right plan of care for you.

For advanced cervical cancers that may spread or have begun to metastasize, your treatment team may use a combination of surgery, radiation therapy, or chemotherapy in your plan of care. Our researchers are also working on better chemotherapy drugs for advanced cervical cancers through our program of clinical trials.

Our multidisciplinary team will devise a treatment strategy for you based on the stage of the cervical cancer, the size of the tumor, the surrounding tissues that may be affected, and whether the cancer has spread to other parts of the body. We also take into consideration your age and whether you wish to have children.

The earlier that cervical cancer is diagnosed and treated, the more likely it can be effectively cured. We typically treat cervical cancer with surgery, in some cases combined with radiation therapy, chemotherapy, or both.

For early-stage cancers in which abnormal cells are found in the cervix, our doctors may recommend a loop electrosurgical excision procedure (LEEP), in which an electrical current through a thin wire loop is used to remove the sample tissue. LEEP takes only about ten minutes under local anesthetic.

Alternatively or in addition to a LEEP procedure, our doctors may recommend a cone biopsy (conization) to more precisely remove a cone-shaped piece of tissue from the cervix with a scalpel. A cone biopsy is performed in an operating room and may include general anesthesia.

More than 90 percent of early-stage cancers are treated successfully with these surgical procedures and do not require any further treatment.

MINIMALLY INVASIVE SURGERY

For early-stage cervical cancers that are confined to the cervix, our doctors may recommend a hysterectomy, a type of surgery that involves removing the uterus entirely. The surgeon may also need to remove some tissue next to the uterus and cervix, as well as lymph nodes from the pelvis, to examine them for cancer cells.

At , the majority of these operations, known as radical hysterectomies, are performed minimally invasively — either with laparoscopy or robotics. Our surgeons have been leaders in adopting these techniques, which typically offer several advantages over traditional, open abdominal surgery for early-stage as well as more-advanced cervical cancer, such as shorter hospital stays, less risk for infection, and lower cost.

With laparoscopy, a thin, lighted tube with a video camera at its tip (a laparoscope) is inserted through a tiny incision in the abdominal wall. The surgeon can operate through this minor surgical “port” using specially designed surgical instruments.

We were also the first cancer hospital to acquire the state-of-the-art robotic da Vinci® Surgical System platform to assist in minimally invasive cancer surgeries. The use of this system during surgery can often result in less pain and faster recovery for patients.

To remove as few pelvic lymph nodes as possible when assessing the extent to which cervical cancer has spread, our doctors pioneered an approach called sentinel lymph node mapping (or intraoperative lymphatic mapping). Today, we are one of the few cancer hospitals in the United States using this approach.

During many cervical cancer surgeries, we use a dye that can be traced with imaging techniques to identify the first lymph node (the sentinel node) to which cancer cells would travel after leaving the cervix. If this node is free of cancer cells, our surgeons do not remove additional lymph nodes. If the sentinel node does contain cancer cells, the surgeon removes additional lymph nodes for further examination.

The goal of using this technique is to treat the cancer while removing as few lymph nodes as possible, which can result in a shorter surgery and fewer side effects such as swelling of the legs, known as lymphedema.

FERTILITY-SPARING RADICAL TRACHELECTOMY

Radical Trachelectomy–During the operation, the outlined area — which includes the cervix (the lower part of the uterus that extends into the upper end of the vagina) and surrounding tissue — is removed. The healthy uterus (located above) is preserved and reattached to the vagina (located below).

During the Operation–Using either minimally invasive or traditional “open” surgery, the surgeon removes the cervix and some of the pelvic lymph nodes. If the edge of the cervical tissue closest to the uterus is free of cancer cells, only the cervix is removed, rather than the entire uterus. The remaining portion of the uterus is left intact and is sutured to the vagina, creating a new cervix.

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ADMISSION

On the day of your operation you will be admitted to the Theatre Direct Admission  area or into the  the surgical Wards.A relative or friend can stay with you in the TDA area, while you wait. When you have gone to the theatre, your possessions will be taken to the main Gynaecology Ward and put into the bed space allocated to you. You will be brought back to the ward after your operation

PREPARATION FOR YOUR OPERATION

You will need to have a bath or shower in the morning, before coming into hospital, as discussed at your Pre-operative Assessment appointment.

While you are in the TDA area you will be visited by the following people:

           A Doctor, who will visit you to see if you have any last minute questions about your operation. If you did not sign a consent form at the Pre-operative Assessment clinic this will now be done with you. The consent form should clearly state what operation you are having, the potential benefits and the risks involved. Please read the form carefully before signing it. You will be given a copy to keep.

          The Anaesthetist, who will see you to discuss what type of anaesthetic you will have, and the different ways of controlling your pain after the operation.

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